2022


Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq.
Joseph M Replogle, Reuben A Saunders, Angela N Pogson, Jeffrey A Hussmann, Alexander Lenail, Alina Guna, Lauren Mascibroda, Eric J Wagner, Karen Adelman, Gila Lithwick-Yanai, Nika Iremadze, Florian Oberstrass, Doron Lipson, Jessica L Bonnar, Marco Jost, Thomas M Norman, Jonathan S Weissman
Cell


Variant to function mapping at single-cell resolution through network propagation.
Fulong Yu, Liam D Cato, Chen Weng, L Alexander Liggett, Soyoung Jeon, Keren Xu, Charleston W K Chiang, Joseph L Wiemels, Jonathan S Weissman, Adam J de Smith, Vijay G Sankaran
Nature biotechnology


Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution.
Dian Yang, Matthew G Jones, Santiago Naranjo, William M Rideout, Kyung Hoi Joseph Min, Raymond Ho, Wei Wu, Joseph M Replogle, Jennifer L Page, Jeffrey J Quinn, Felix Horns, Xiaojie Qiu, Michael Z Chen, William A Freed-Pastor, Christopher S McGinnis, David M Patterson, Zev J Gartner, Eric D Chow, Trever G Bivona, Michelle M Chan, Nir Yosef, Tyler Jacks, Jonathan S Weissman
Cell


OpenCell: Endogenous tagging for the cartography of human cellular organization.
Nathan H Cho, Keith C Cheveralls, Andreas-David Brunner, Kibeom Kim, André C Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y Li, Hera Canaj, James Y S Kim, Edna M Stewart, Christian Gnann, Frank McCarthy, Joana P Cabrera, Rachel M Brunetti, Bryant B Chhun, Greg Dingle, Marco Y Hein, Bo Huang, Shalin B Mehta, Jonathan S Weissman, Rafael Gómez-Sjöberg, Daniel N Itzhak, Loïc A Royer, Matthias Mann, Manuel D Leonetti
Science


Variant to function mapping at single-cell resolution through network propagation.
Fulong Yu, Liam D Cato, Chen Weng, L Alexander Liggett, Soyoung Jeon, Keren Xu, Charleston W K Chiang, Joseph L Wiemels, Jonathan S Weissman, Adam J de Smith, Vijay G Sankaran
biorxiv


Mapping transcriptomic vector fields of single cells.
Xiaojie Qiu, Yan Zhang, Jorge D Martin-Rufino, Chen Weng, Shayan Hosseinzadeh, Dian Yang, Angela N Pogson, Marco Y Hein, Kyung Hoi Joseph Min, Li Wang, Emanuelle I Grody, Matthew J Shurtleff, Ruoshi Yuan, Song Xu, Yian Ma, Joseph M Replogle, Eric S Lander, Spyros Darmanis, Ivet Bahar, Vijay G Sankaran, Jianhua Xing, Jonathan S Weissman
Cell


BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2.
Avi J Samelson, Quang Dinh Tran, Rémy Robinot, Lucia Carrau, Veronica V Rezelj, Alice Mac Kain, Merissa Chen, Gokul N Ramadoss, Xiaoyan Guo, Shion A Lim, Irene Lui, James K Nuñez, Sarah J Rockwood, Jianhui Wang, Na Liu, Jared Carlson-Stevermer, Jennifer Oki, Travis Maures, Kevin Holden, Jonathan S Weissman, James A Wells, Bruce R Conklin, Benjamin R TenOever, Lisa A Chakrabarti, Marco Vignuzzi, Ruilin Tian, Martin Kampmann
Nature cell biology


Peroxisome function relies on organelle-associated mRNA translation.
Noa Dahan, Yury S Bykov, Elizabeth A Boydston, Amir Fadel, Zohar Gazi, Hodaya Hochberg-Laufer, James Martenson, Vlad Denic, Yaron Shav-Tal, Jonathan S Weissman, Naama Aviram, Einat Zalckvar, Maya Schuldiner
Science advances

2021


The dark proteome: translation from noncanonical open reading frames.
Bradley W Wright, Zixin Yi, Jonathan S Weissman, Jin Chen
Trends in cell biology


Functional single-cell genomics of human cytomegalovirus infection.
Marco Y Hein, Jonathan S Weissman
Nature biotechnology


Mapping the genetic landscape of DNA double-strand break repair.
Jeffrey A Hussmann, Jia Ling, Purnima Ravisankar, Jun Yan, Ann Cirincione, Albert Xu, Danny Simpson, Dian Yang, Anne Bothmer, Cecilia Cotta-Ramusino, Jonathan S Weissman, Britt Adamson
Cell


Enhanced prime editing systems by manipulating cellular determinants of editing outcomes.
Peter J Chen, Jeffrey A Hussmann, Jun Yan, Friederike Knipping, Purnima Ravisankar, Pin-Fang Chen, Cidi Chen, James W Nelson, Gregory A Newby, Mustafa Sahin, Mark J Osborn, Jonathan S Weissman, Britt Adamson, David R Liu
Cell


Structured elements drive extensive circular RNA translation.
Chun-Kan Chen, Ran Cheng, Janos Demeter, Jin Chen, Shira Weingarten-Gabbay, Lihua Jiang, Michael P Snyder, Jonathan S Weissman, Eran Segal, Peter K Jackson, Howard Y Chang
Molecular cell


An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput CRISPRi screens.
Robert Coukos, David Yao, Mateo I Sanchez, Eric T Strand, Meagan E Olive, Namrata D Udeshi, Jonathan S Weissman, Steven A Carr, Michael C Bassik, Alice Y Ting
eLife


Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning.
Luke W Koblan, Mandana Arbab, Max W Shen, Jeffrey A Hussmann, Andrew V Anzalone, Jordan L Doman, Gregory A Newby, Dian Yang, Beverly Mok, Joseph M Replogle, Albert Xu, Tyler A Sisley, Jonathan S Weissman, Britt Adamson, David R Liu
Nature biotechnology


Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells.
Maxence Le Vasseur, Jonathan Friedman, Marco Jost, Jiawei Xu, Justin Yamada, Martin Kampmann, Max A Horlbeck, Michelle R Salemi, Brett S Phinney, Jonathan S Weissman, Jodi Nunnari
eLife


CRISPR-based functional genomics in human dendritic cells.
Marco Jost, Amy N Jacobson, Jeffrey A Hussmann, Giana Cirolia, Michael A Fischbach, Jonathan S Weissman
eLife


Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing.
James K Nuñez, Jin Chen, Greg C Pommier, J Zachery Cogan, Joseph M Replogle, Carmen Adriaens, Gokul N Ramadoss, Quanming Shi, King L Hung, Avi J Samelson, Angela N Pogson, James Y S Kim, Amanda Chung, Manuel D Leonetti, Howard Y Chang, Martin Kampmann, Bradley E Bernstein, Volker Hovestadt, Luke A Gilbert, Jonathan S Weissman
Cell


Regulation of translation by methylation multiplicity of 18S rRNA.
Kuanqing Liu, Daniel A Santos, Jeffrey A Hussmann, Yun Wang, Benjamin M Sutter, Jonathan S Weissman, Benjamin P Tu
Cell reports


Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression.
Lei S Qi, Matthew H Larson, Luke A Gilbert, Jennifer A Doudna, Jonathan S Weissman, Adam P Arkin, Wendell A Lim
Cell


BRD2 inhibition blocks SARS-CoV-2 infection in vitro by reducing transcription of the host cell receptor ACE2.
Ruilin Tian, Avi J Samelson, Veronica V Rezelj, Merissa Chen, Gokul N Ramadoss, Xiaoyan Guo, Alice Mac Kain, Quang Dinh Tran, Shion A Lim, Irene Lui, James Nunez, Sarah J Rockwood, Na Liu, Jared Carlson-Stevermer, Jennifer Oki, Travis Maures, Kevin Holden, Jonathan S Weissman, James A Wells, Bruce Conklin, Marco Vignuzzi, Martin Kampmann
biorxiv


Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts.
Jeffrey J Quinn, Matthew G Jones, Ross A Okimoto, Shigeki Nanjo, Michelle M Chan, Nir Yosef, Trever G Bivona, Jonathan S Weissman
Science


High-content imaging-based pooled CRISPR screens in mammalian cells.
Xiaowei Yan, Nico Stuurman, Susana A Ribeiro, Marvin E Tanenbaum, Max A Horlbeck, Christina R Liem, Marco Jost, Jonathan S Weissman, Ronald D Vale
The Journal of cell biology


A CRISPR/Cas9-Engineered ARID1A-Deficient Human Gastric Cancer Organoid Model Reveals Essential and Nonessential Modes of Oncogenic Transformation
Yuan-Hung Lo, Kevin S Kolahi, Yuhong Du, Chiung-Ying Chang, Andrey Krokhotin, Ajay Nair, Walter D Sobba, Kasper Karlsson, Sunny J Jones, Teri A Longacre, Amanda T Mah, Bahar Tercan, Alexandra Sockell, Hang Xu, Jose A Seoane, Jin Chen, Ilya Shmulevich, Jonathan S Weissman, Christina Curtis, Andrea Califano, Haian Fu, Gerald R Crabtree, Calvin J Kuo
Cancer discovery

2020


Genome-Scale Perturbation of Long Noncoding RNA Expression Using CRISPR Interference.
S John Liu, Max A Horlbeck, Jonathan S Weissman, Daniel A Lim
Methods in molecular biology


Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients.
Lakshmi E Miller-Vedam, Bastian Bräuning, Katerina D Popova, Nicole T Schirle Oakdale, Jessica L Bonnar, Jesuraj R Prabu, Elizabeth A Boydston, Natalia Sevillano, Matthew J Shurtleff, Robert M Stroud, Charles S Craik, Brenda A Schulman, Adam Frost, Jonathan S Weissman
eLife


Mismatch-CRISPRi Reveals the Co-varying Expression-Fitness Relationships of Essential Genes in Escherichia coli and Bacillus subtilis.
John S Hawkins, Melanie R Silvis, Byoung-Mo Koo, Jason M Peters, Hendrik Osadnik, Marco Jost, Cameron C Hearne, Jonathan S Weissman, Horia Todor, Carol A Gross
Cell systems


Conserved Functions of Ether Lipids and Sphingolipids in the Early Secretory Pathway.
Noemi Jiménez-Rojo, Manuel D Leonetti, Valeria Zoni, Adai Colom, Suihan Feng, Namrata R Iyengar, Stefan Matile, Aurélien Roux, Stefano Vanni, Jonathan S Weissman, Howard Riezman
Current biology


Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing.
Ashley Maynard, Caroline E McCoach, Julia K Rotow, Lincoln Harris, Franziska Haderk, D Lucas Kerr, Elizabeth A Yu, Erin L Schenk, Weilun Tan, Alexander Zee, Michelle Tan, Philippe Gui, Tasha Lea, Wei Wu, Anatoly Urisman, Kirk Jones, Rene Sit, Pallav K Kolli, Eric Seeley, Yaron Gesthalter, Daniel D Le, Kevin A Yamauchi, David M Naeger, Sourav Bandyopadhyay, Khyati Shah, Lauren Cech, Nicholas J Thomas, Anshal Gupta, Mayra Gonzalez, Hien Do, Lisa Tan, Bianca Bacaltos, Rafael Gomez-Sjoberg, Matthew Gubens, Thierry Jahan, Johannes R Kratz, David Jablons, Norma Neff, Robert C Doebele, Jonathan Weissman, Collin M Blakely, Spyros Darmanis, Trever G Bivona
Cell


Life span extension by glucose restriction is abrogated by methionine supplementation: Cross-talk between glucose and methionine and implication of methionine as a key regulator of life span.
Ke Zou, Silvia Rouskin, Kevin Dervishi, Mark A McCormick, Arjun Sasikumar, Changhui Deng, Zhibing Chen, Matt Kaeberlein, Rachel B Brem, Michael Polymenis, Brian K Kennedy, Jonathan S Weissman, Jiashun Zheng, Qi Ouyang, Hao Li
Science advances


GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control.
Kelsey L Hickey, Kimberley Dickson, J Zachery Cogan, Joseph M Replogle, Michael Schoof, Karole N D'Orazio, Niladri K Sinha, Jeffrey A Hussmann, Marco Jost, Adam Frost, Rachel Green, Jonathan S Weissman, Kamena K Kostova
Molecular cell


Pharmaceutical-Grade Rigosertib Is a Microtubule-Destabilizing Agent.
Marco Jost, Yuwen Chen, Luke A Gilbert, Max A Horlbeck, Lenno Krenning, Grégory Menchon, Ankit Rai, Min Y Cho, Jacob J Stern, Andrea E Prota, Martin Kampmann, Anna Akhmanova, Michel O Steinmetz, Marvin E Tanenbaum, Jonathan S Weissman
Molecular cell


Polysomes Bypass a 50-Nucleotide Coding Gap Less Efficiently Than Monosomes Due to Attenuation of a 5' mRNA Stem-Loop and Enhanced Drop-off.
Sinéad O'Loughlin, Mark C Capece, Mariia Klimova, Norma M Wills, Arthur Coakley, Ekaterina Samatova, Patrick B F O'Connor, Gary Loughran, Jonathan S Weissman, Pavel V Baranov, Marina V Rodnina, Joseph D Puglisi, John F Atkins
Journal of molecular biology


Inference of single-cell phylogenies from lineage tracing data using Cassiopeia.
Matthew G Jones, Alex Khodaverdian, Jeffrey J Quinn, Michelle M Chan, Jeffrey A Hussmann, Robert Wang, Chenling Xu, Jonathan S Weissman, Nir Yosef
Genome biology


CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma.
S John Liu, Martina Malatesta, Brian V Lien, Parna Saha, Shivani S Thombare, Sung Jun Hong, Leslie Pedraza, Mark Koontz, Kyounghee Seo, Max A Horlbeck, Daniel He, Harjus S Birk, Miten Jain, Hugh E Olsen, Mark Akeson, Jonathan S Weissman, Michelle Monje, Nalin Gupta, David R Raleigh, Erik M Ullian, Daniel A Lim
Genome biology


Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing.
Joseph M Replogle, Thomas M Norman, Albert Xu, Jeffrey A Hussmann, Jin Chen, J Zachery Cogan, Elliott J Meer, Jessica M Terry, Daniel P Riordan, Niranjan Srinivas, Ian T Fiddes, Joseph G Arthur, Luigi J Alvarado, Katherine A Pfeiffer, Tarjei S Mikkelsen, Jonathan S Weissman, Britt Adamson
Nature biotechnology


Pervasive functional translation of noncanonical human open reading frames.
Jin Chen, Andreas-David Brunner, J Zachery Cogan, James K Nuñez, Alexander P Fields, Britt Adamson, Daniel N Itzhak, Jason Y Li, Matthias Mann, Manuel D Leonetti, Jonathan S Weissman
Science


Fitness effects of CRISPR/Cas9-targeting of long noncoding RNA genes.
Max A Horlbeck, S John Liu, Howard Y Chang, Daniel A Lim, Jonathan S Weissman
Nature biotechnology


Titrating gene expression using libraries of systematically attenuated CRISPR guide RNAs.
Marco Jost, Daniel A Santos, Reuben A Saunders, Max A Horlbeck, John S Hawkins, Sonia M Scaria, Thomas M Norman, Jeffrey A Hussmann, Christina R Liem, Carol A Gross, Jonathan S Weissman
Nature biotechnology


The microtubule regulator ringer functions downstream from the RNA repair/splicing pathway to promote axon regeneration
Ernest J Monahan Vargas, Andrew J Matamoros, Jingyun Qiu, Calvin H Jan, Qin Wang, David Gorczyca, Tina W Han, Jonathan S Weissman, Yuh Nung Jan, Swati Banerjee, Yuanquan Song
Genes & development

2019


The ER membrane protein complex is required to ensure correct topology and stable expression of flavivirus polyproteins.
Ashley M Ngo, Matthew J Shurtleff, Katerina D Popova, Jessie Kulsuptrakul, Jonathan S Weissman, Andreas S Puschnik
eLife


New factors for protein transport identified by a genome-wide CRISPRi screen in mammalian cells.
Laia Bassaganyas, Stephanie J Popa, Max Horlbeck, Claudia Puri, Sarah E Stewart, Felix Campelo, Anupama Ashok, Cristian M Butnaru, Nathalie Brouwers, Kartoosh Heydari, Jean Ripoche, Jonathan Weissman, David C Rubinsztein, Randy Schekman, Vivek Malhotra, Kevin Moreau, Julien Villeneuve
The Journal of cell biology


Exploring genetic interaction manifolds constructed from rich single-cell phenotypes.
Thomas M Norman, Max A Horlbeck, Joseph M Replogle, Alex Y Ge, Albert Xu, Marco Jost, Luke A Gilbert, Jonathan S Weissman
Science


MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices.
Christopher S McGinnis, David M Patterson, Juliane Winkler, Daniel N Conrad, Marco Y Hein, Vasudha Srivastava, Jennifer L Hu, Lyndsay M Murrow, Jonathan S Weissman, Zena Werb, Eric D Chow, Zev J Gartner
Nature methods


Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether.
Sandra Elizabeth Torres, Ciara M Gallagher, Lars Plate, Meghna Gupta, Christina R Liem, Xiaoyan Guo, Ruilin Tian, Robert M Stroud, Martin Kampmann, Jonathan S Weissman, Peter Walter
eLife


Chaperone-mediated reflux of secretory proteins to the cytosol during endoplasmic reticulum stress.
Aeid Igbaria, Philip I Merksamer, Ala Trusina, Firehiwot Tilahun, Jeffrey R Johnson, Onn Brandman, Nevan J Krogan, Jonathan S Weissman, Feroz R Papa
PNAS


Molecular recording of mammalian embryogenesis.
Michelle M Chan, Zachary D Smith, Stefanie Grosswendt, Helene Kretzmer, Thomas M Norman, Britt Adamson, Marco Jost, Jeffrey J Quinn, Dian Yang, Matthew G Jones, Alex Khodaverdian, Nir Yosef, Alexander Meissner, Jonathan S Weissman
Nature


Cycloheximide can distort measurements of mRNA levels and translation efficiency.
Daniel A Santos, Lei Shi, Benjamin P Tu, Jonathan S Weissman
Nucleic acids research


Cellular response to small molecules that selectively stall protein synthesis by the ribosome.
Nadège Liaud, Max A Horlbeck, Luke A Gilbert, Ketrin Gjoni, Jonathan S Weissman, Jamie H D Cate
PLoS genetics


Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids.
Manuele Piccolis, Laura M Bond, Martin Kampmann, Pamela Pulimeno, Chandramohan Chitraju, Christina B K Jayson, Laura P Vaites, Sebastian Boland, Zon Weng Lai, Katlyn R Gabriel, Shane D Elliott, Joao A Paulo, J Wade Harper, Jonathan S Weissman, Tobias C Walther, Robert V Farese
Molecular cell

2018


Ribosome Profiling: Global Views of Translation.
Nicholas T Ingolia, Jeffrey A Hussmann, Jonathan S Weissman
Cold Spring Harbor perspectives in biology


Mapping the Genetic Landscape of Human Cells.
Max A Horlbeck, Albert Xu, Min Wang, Neal K Bennett, Chong Y Park, Derek Bogdanoff, Britt Adamson, Eric D Chow, Martin Kampmann, Tim R Peterson, Ken Nakamura, Michael A Fischbach, Jonathan S Weissman, Luke A Gilbert
Cell


Reprogramming human T cell function and specificity with non-viral genome targeting.
Theodore L Roth, Cristina Puig-Saus, Ruby Yu, Eric Shifrut, Julia Carnevale, P Jonathan Li, Joseph Hiatt, Justin Saco, Paige Krystofinski, Han Li, Victoria Tobin, David N Nguyen, Michael R Lee, Amy L Putnam, Andrea L Ferris, Jeff W Chen, Jean-Nicolas Schickel, Laurence Pellerin, David Carmody, Gorka Alkorta-Aranburu, Daniela Del Gaudio, Hiroyuki Matsumoto, Montse Morell, Ying Mao, Min Cho, Rolen M Quadros, Channabasavaiah B Gurumurthy, Baz Smith, Michael Haugwitz, Stephen H Hughes, Jonathan S Weissman, Kathrin Schumann, Jonathan H Esensten, Andrew P May, Alan Ashworth, Gary M Kupfer, Siri Atma W Greeley, Rosa Bacchetta, Eric Meffre, Maria Grazia Roncarolo, Neil Romberg, Kevan C Herold, Antoni Ribas, Manuel D Leonetti, Alexander Marson
Nature


Engineering ER-stress dependent non-conventional mRNA splicing.
Weihan Li, Voytek Okreglak, Jirka Peschek, Philipp Kimmig, Meghan Zubradt, Jonathan S Weissman, Peter Walter
eLife


Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70).
Hao Shao, Xiaokai Li, Michael A Moses, Luke A Gilbert, Chakrapani Kalyanaraman, Zapporah T Young, Margarita Chernova, Sara N Journey, Jonathan S Weissman, Byron Hann, Matthew P Jacobson, Len Neckers, Jason E Gestwicki
Journal of medicinal chemistry


The helicase Ded1p controls use of near-cognate translation initiation codons in 5' UTRs.
Ulf-Peter Guenther, David E Weinberg, Meghan M Zubradt, Frank A Tedeschi, Brittany N Stawicki, Leah L Zagore, Gloria A Brar, Donny D Licatalosi, David P Bartel, Jonathan S Weissman, Eckhard Jankowsky
Nature


The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins.
Matthew J Shurtleff, Daniel N Itzhak, Jeffrey A Hussmann, Nicole T Schirle Oakdale, Elizabeth A Costa, Martin Jonikas, Jimena Weibezahn, Katerina D Popova, Calvin H Jan, Pavel Sinitcyn, Shruthi S Vembar, Hilda Hernandez, Jürgen Cox, Alma L Burlingame, Jeffrey L Brodsky, Adam Frost, Georg Hh Borner, Jonathan S Weissman
eLife


Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates.
Zhou Yu, Lauren E Surface, Chong Yon Park, Max A Horlbeck, Gregory A Wyant, Monther Abu-Remaileh, Timothy R Peterson, David M Sabatini, Jonathan S Weissman, Erin K O'Shea
eLife


Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element.
Seung Woo Cho, Jin Xu, Ruping Sun, Maxwell R Mumbach, Ava C Carter, Y Grace Chen, Kathryn E Yost, Jeewon Kim, Jing He, Stephanie A Nevins, Suet-Feung Chin, Carlos Caldas, S John Liu, Max A Horlbeck, Daniel A Lim, Jonathan S Weissman, Christina Curtis, Howard Y Chang
Cell


A Stress Response that Monitors and Regulates mRNA Structure Is Central to Cold Shock Adaptation.
Yan Zhang, David H Burkhardt, Silvi Rouskin, Gene-Wei Li, Jonathan S Weissman, Carol A Gross
Molecular cell


Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins.
Alexander J Martinko, Charles Truillet, Olivier Julien, Juan E Diaz, Max A Horlbeck, Gordon Whiteley, Josip Blonder, Jonathan S Weissman, Sourav Bandyopadhyay, Michael J Evans, James A Wells
eLife


Defining the physiological role of SRP in protein-targeting efficiency and specificity.
Elizabeth A Costa, Kelly Subramanian, Jodi Nunnari, Jonathan S Weissman
Science


Lipid Homeostasis Is Maintained by Dual Targeting of the Mitochondrial PE Biosynthesis Enzyme to the ER.
Jonathan R Friedman, Muthukumar Kannan, Alexandre Toulmay, Calvin H Jan, Jonathan S Weissman, William A Prinz, Jodi Nunnari
Developmental cell

2017


CRISPR Approaches to Small Molecule Target Identification.
Marco Jost, Jonathan S Weissman
ACS chemical biology


The Human Cell Atlas.
Aviv Regev, Sarah A Teichmann, Eric S Lander, Ido Amit, Christophe Benoist, Ewan Birney, Bernd Bodenmiller, Peter Campbell, Piero Carninci, Menna Clatworthy, Hans Clevers, Bart Deplancke, Ian Dunham, James Eberwine, Roland Eils, Wolfgang Enard, Andrew Farmer, Lars Fugger, Berthold Göttgens, Nir Hacohen, Muzlifah Haniffa, Martin Hemberg, Seung Kim, Paul Klenerman, Arnold Kriegstein, Ed Lein, Sten Linnarsson, Emma Lundberg, Joakim Lundeberg, Partha Majumder, John C Marioni, Miriam Merad, Musa Mhlanga, Martijn Nawijn, Mihai Netea, Garry Nolan, Dana Pe'er, Anthony Phillipakis, Chris P Ponting, Stephen Quake, Wolf Reik, Orit Rozenblatt-Rosen, Joshua Sanes, Rahul Satija, Ton N Schumacher, Alex Shalek, Ehud Shapiro, Padmanee Sharma, Jay W Shin, Oliver Stegle, Michael Stratton, Michael J T Stubbington, Fabian J Theis, Matthias Uhlen, Alexander van Oudenaarden, Allon Wagner, Fiona Watt, Jonathan Weissman, Barbara Wold, Ramnik Xavier, Nir Yosef, Human Cell Atlas Meeting Participants
eLife


Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform.
Kirk J Wangensteen, Yue J Wang, Zhixun Dou, Amber W Wang, Elham Mosleh-Shirazi, Max A Horlbeck, Luke A Gilbert, Jonathan S Weissman, Shelley L Berger, Klaus H Kaestner
Hepatology


Inducible and multiplex gene regulation using CRISPR-Cpf1-based transcription factors.
Y Esther Tak, Benjamin P Kleinstiver, James K Nuñez, Jonathan Y Hsu, Joy E Horng, Jingyi Gong, Jonathan S Weissman, J Keith Joung
Nature methods


Combined CRISPRi/a-Based Chemical Genetic Screens Reveal that Rigosertib Is a Microtubule-Destabilizing Agent.
Marco Jost, Yuwen Chen, Luke A Gilbert, Max A Horlbeck, Lenno Krenning, Grégory Menchon, Ankit Rai, Min Y Cho, Jacob J Stern, Andrea E Prota, Martin Kampmann, Anna Akhmanova, Michel O Steinmetz, Marvin E Tanenbaum, Jonathan S Weissman
Molecular cell


CAT-tailing as a fail-safe mechanism for efficient degradation of stalled nascent polypeptides.
Kamena K Kostova, Kelsey L Hickey, Beatriz A Osuna, Jeffrey A Hussmann, Adam Frost, David E Weinberg, Jonathan S Weissman
Science


Suppression of B-cell development genes is key to glucocorticoid efficacy in treatment of acute lymphoblastic leukemia.
Karina A Kruth, Mimi Fang, Dawne N Shelton, Ossama Abu-Halawa, Ryan Mahling, Hongxing Yang, Jonathan S Weissman, Mignon L Loh, Markus Müschen, Sarah K Tasian, Michael C Bassik, Martin Kampmann, Miles A Pufall
Blood


Operon mRNAs are organized into ORF-centric structures that predict translation efficiency.
David H Burkhardt, Silvi Rouskin, Yan Zhang, Gene-Wei Li, Jonathan S Weissman, Carol A Gross
eLife


Translation from unconventional 5' start sites drives tumour initiation.
Ataman Sendoel, Joshua G Dunn, Edwin H Rodriguez, Shruti Naik, Nicholas C Gomez, Brian Hurwitz, John Levorse, Brian D Dill, Daniel Schramek, Henrik Molina, Jonathan S Weissman, Elaine Fuchs
Nature

2016


Model-guided optogenetic study of PKA signaling in budding yeast.
Jacob Stewart-Ornstein, Susan Chen, Rajat Bhatnagar, Jonathan S Weissman, Hana El-Samad
Molecular biology of the cell


A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response.
Britt Adamson, Thomas M Norman, Marco Jost, Min Y Cho, James K Nuñez, Yuwen Chen, Jacqueline E Villalta, Luke A Gilbert, Max A Horlbeck, Marco Y Hein, Ryan A Pak, Andrew N Gray, Carol A Gross, Atray Dixit, Oren Parnas, Aviv Regev, Jonathan S Weissman
Cell


Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens.
Atray Dixit, Oren Parnas, Biyu Li, Jenny Chen, Charles P Fulco, Livnat Jerby-Arnon, Nemanja D Marjanovic, Danielle Dionne, Tyler Burks, Raktima Raychowdhury, Britt Adamson, Thomas M Norman, Eric S Lander, Jonathan S Weissman, Nir Friedman, Aviv Regev
Cell


CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells.
S John Liu, Max A Horlbeck, Seung Woo Cho, Harjus S Birk, Martina Malatesta, Daniel He, Frank J Attenello, Jacqueline E Villalta, Min Y Cho, Yuwen Chen, Mohammad A Mandegar, Michael P Olvera, Luke A Gilbert, Bruce R Conklin, Howard Y Chang, Jonathan S Weissman, Daniel A Lim
Science


The mTOR Complex Controls HIV Latency.
Emilie Besnard, Shweta Hakre, Martin Kampmann, Hyung W Lim, Nina N Hosmane, Alyssa Martin, Michael C Bassik, Erik Verschueren, Emilie Battivelli, Jonathan Chan, J Peter Svensson, Andrea Gramatica, Ryan J Conrad, Melanie Ott, Warner C Greene, Nevan J Krogan, Robert F Siliciano, Jonathan S Weissman, Eric Verdin
Cell host & microbe


The SND proteins constitute an alternative targeting route to the endoplasmic reticulum.
Naama Aviram, Tslil Ast, Elizabeth A Costa, Eric C Arakel, Silvia G Chuartzman, Calvin H Jan, Sarah Haßdenteufel, Johanna Dudek, Martin Jung, Stefan Schorr, Richard Zimmermann, Blanche Schwappach, Jonathan S Weissman, Maya Schuldiner
Nature


Plastid: nucleotide-resolution analysis of next-generation sequencing and genomics data.
Joshua G Dunn, Jonathan S Weissman
BMC genomics


DMS-MaPseq for genome-wide or targeted RNA structure probing in vivo.
Meghan Zubradt, Paromita Gupta, Sitara Persad, Alan M Lambowitz, Jonathan S Weissman, Silvi Rouskin
Nature methods


Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation.
Max A Horlbeck, Luke A Gilbert, Jacqueline E Villalta, Britt Adamson, Ryan A Pak, Yuwen Chen, Alexander P Fields, Chong Yon Park, Jacob E Corn, Martin Kampmann, Jonathan S Weissman
eLife


Dynamic translation regulation in Caulobacter cell cycle control.
Jared M Schrader, Gene-Wei Li, W Seth Childers, Adam M Perez, Jonathan S Weissman, Lucy Shapiro, Harley H McAdams
PNAS


Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma.
Amit J Sabnis, Christopher J Guerriero, Victor Olivas, Anin Sayana, Jonathan Shue, Jennifer Flanagan, Saurabh Asthana, Adrienne W Paton, James C Paton, Jason E Gestwicki, Peter Walter, Jonathan S Weissman, Peter Wipf, Jeffrey L Brodsky, Trever G Bivona
PNAS


Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity.
Duy P Nguyen, Yuichiro Miyaoka, Luke A Gilbert, Steven J Mayerl, Brian H Lee, Jonathan S Weissman, Bruce R Conklin, James A Wells
Nature communications


Htm1p-Pdi1p is a folding-sensitive mannosidase that marks N-glycoproteins for ER-associated protein degradation.
Yi-Chang Liu, Danica Galonić Fujimori, Jonathan S Weissman
PNAS


Versatile in vivo regulation of tumor phenotypes by dCas9-mediated transcriptional perturbation.
Christian J Braun, Peter M Bruno, Max A Horlbeck, Luke A Gilbert, Jonathan S Weissman, Michael T Hemann
PNAS


A scalable strategy for high-throughput GFP tagging of endogenous human proteins.
Manuel D Leonetti, Sayaka Sekine, Daichi Kamiyama, Jonathan S Weissman, Bo Huang
PNAS


A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria.
Jason M Peters, Alexandre Colavin, Handuo Shi, Tomasz L Czarny, Matthew H Larson, Spencer Wong, John S Hawkins, Candy H S Lu, Byoung-Mo Koo, Elizabeth Marta, Anthony L Shiver, Evan H Whitehead, Jonathan S Weissman, Eric D Brown, Lei S Qi, Kerwyn Casey Huang, Carol A Gross
Cell


Single-cell analysis of long non-coding RNAs in the developing human neocortex.
Siyuan John Liu, Tomasz J Nowakowski, Alex A Pollen, Jan H Lui, Max A Horlbeck, Frank J Attenello, Daniel He, Jonathan S Weissman, Arnold R Kriegstein, Aaron A Diaz, Daniel A Lim
Genome biology


Versatile protein tagging in cells with split fluorescent protein.
Daichi Kamiyama, Sayaka Sekine, Benjamin Barsi-Rhyne, Jeffrey Hu, Baohui Chen, Luke A Gilbert, Hiroaki Ishikawa, Manuel D Leonetti, Wallace F Marshall, Jonathan S Weissman, Bo Huang
Nature communications


Nucleosomes impede Cas9 access to DNA in vivo and in vitro.
Max A Horlbeck, Lea B Witkowsky, Benjamin Guglielmi, Joseph M Replogle, Luke A Gilbert, Jacqueline E Villalta, Sharon E Torigoe, Robert Tjian, Jonathan S Weissman
eLife


CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs.
Mohammad A Mandegar, Nathaniel Huebsch, Ekaterina B Frolov, Edward Shin, Annie Truong, Michael P Olvera, Amanda H Chan, Yuichiro Miyaoka, Kristin Holmes, C Ian Spencer, Luke M Judge, David E Gordon, Tilde V Eskildsen, Jacqueline E Villalta, Max A Horlbeck, Luke A Gilbert, Nevan J Krogan, Søren P Sheikh, Jonathan S Weissman, Lei S Qi, Po-Lin So, Bruce R Conklin
Cell stem cell

2015


A Regression-Based Analysis of Ribosome-Profiling Data Reveals a Conserved Complexity to Mammalian Translation.
Alexander P Fields, Edwin H Rodriguez, Marko Jovanovic, Noam Stern-Ginossar, Brian J Haas, Philipp Mertins, Raktima Raychowdhury, Nir Hacohen, Steven A Carr, Nicholas T Ingolia, Aviv Regev, Jonathan S Weissman
Molecular cell


[KIL-d] Protein Element Confers Antiviral Activity via Catastrophic Viral Mutagenesis.
Genjiro Suzuki, Jonathan S Weissman, Motomasa Tanaka
Molecular cell


Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis.
Daniel J Anderson, Ronan Le Moigne, Stevan Djakovic, Brajesh Kumar, Julie Rice, Steve Wong, Jinhai Wang, Bing Yao, Eduardo Valle, Szerenke Kiss von Soly, Antonett Madriaga, Ferdie Soriano, Mary-Kamala Menon, Zhi Yong Wu, Martin Kampmann, Yuwen Chen, Jonathan S Weissman, Blake T Aftab, F Michael Yakes, Laura Shawver, Han-Jie Zhou, David Wustrow, Mark Rolfe
Cancer cell


Ribosome profiling reveals the what, when, where and how of protein synthesis.
Gloria A Brar, Jonathan S Weissman
Nature reviews. Molecular cell biology


Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits.
Diego Acosta-Alvear, Min Y Cho, Thomas Wild, Tonia J Buchholz, Alana G Lerner, Olga Simakova, Jamie Hahn, Neha Korde, Ola Landgren, Irina Maric, Chunaram Choudhary, Peter Walter, Jonathan S Weissman, Martin Kampmann
eLife


Regulation of mRNA translation during mitosis.
Marvin E Tanenbaum, Noam Stern-Ginossar, Jonathan S Weissman, Ronald D Vale
eLife


Next-generation libraries for robust RNA interference-based genome-wide screens.
Martin Kampmann, Max A Horlbeck, Yuwen Chen, Jordan C Tsai, Michael C Bassik, Luke A Gilbert, Jacqueline E Villalta, S Chul Kwon, Hyeshik Chang, V Narry Kim, Jonathan S Weissman
PNAS


LOCAL TRANSLATION. Response to Comment on "Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling".
Calvin H Jan, Christopher C Williams, Jonathan S Weissman
Science


Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response.
Carmela Sidrauski, Jordan C Tsai, Martin Kampmann, Brian R Hearn, Punitha Vedantham, Priyadarshini Jaishankar, Masaaki Sokabe, Aaron S Mendez, Billy W Newton, Edward L Tang, Erik Verschueren, Jeffrey R Johnson, Nevan J Krogan, Christopher S Fraser, Jonathan S Weissman, Adam R Renslo, Peter Walter
eLife


Corrigendum: functional genomics platform for pooled screening and generation of mammalian genetic interaction maps.
Martin Kampmann, Michael C Bassik, Jonathan S Weissman
Nature protocols


Biotechnology. A prudent path forward for genomic engineering and germline gene modification.
David Baltimore, Paul Berg, Michael Botchan, Dana Carroll, R Alta Charo, George Church, Jacob E Corn, George Q Daley, Jennifer A Doudna, Marsha Fenner, Henry T Greely, Martin Jinek, G Steven Martin, Edward Penhoet, Jennifer Puck, Samuel H Sternberg, Jonathan S Weissman, Keith R Yamamoto
Science


Immunogenetics. Dynamic profiling of the protein life cycle in response to pathogens.
Marko Jovanovic, Michael S Rooney, Philipp Mertins, Dariusz Przybylski, Nicolas Chevrier, Rahul Satija, Edwin H Rodriguez, Alexander P Fields, Schraga Schwartz, Raktima Raychowdhury, Maxwell R Mumbach, Thomas Eisenhaure, Michal Rabani, Dave Gennert, Diana Lu, Toni Delorey, Jonathan S Weissman, Steven A Carr, Nir Hacohen, Aviv Regev
Science


Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer.
Xiaokai Li, Teresa Colvin, Jennifer N Rauch, Diego Acosta-Alvear, Martin Kampmann, Bryan Dunyak, Byron Hann, Blake T Aftab, Megan Murnane, Min Cho, Peter Walter, Jonathan S Weissman, Michael Y Sherman, Jason E Gestwicki
Molecular cancer therapeutics


Protein synthesis. Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains.
Peter S Shen, Joseph Park, Yidan Qin, Xueming Li, Krishna Parsawar, Matthew H Larson, James Cox, Yifan Cheng, Alan M Lambowitz, Jonathan S Weissman, Onn Brandman, Adam Frost
Science

2014


Causal signals between codon bias, mRNA structure, and the efficiency of translation and elongation.
Cristina Pop, Silvi Rouskin, Nicholas T Ingolia, Lu Han, Eric M Phizicky, Jonathan S Weissman, Daphne Koller
Molecular systems biology


Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds.
Jesse G Zalatan, Michael E Lee, Ricardo Almeida, Luke A Gilbert, Evan H Whitehead, Marie La Russa, Jordan C Tsai, Jonathan S Weissman, John E Dueber, Lei S Qi, Wendell A Lim
Cell


Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling.
Calvin H Jan, Christopher C Williams, Jonathan S Weissman
Science


Targeting and plasticity of mitochondrial proteins revealed by proximity-specific ribosome profiling.
Christopher C Williams, Calvin H Jan, Jonathan S Weissman
Science


The general mode of translation inhibition by macrolide antibiotics.
Krishna Kannan, Pinal Kanabar, David Schryer, Tanja Florin, Eugene Oh, Neil Bahroos, Tanel Tenson, Jonathan S Weissman, Alexander S Mankin
PNAS


Genetic influences on translation in yeast.
Frank W Albert, Dale Muzzey, Jonathan S Weissman, Leonid Kruglyak
PLoS genetics


A protein-tagging system for signal amplification in gene expression and fluorescence imaging.
Marvin E Tanenbaum, Luke A Gilbert, Lei S Qi, Jonathan S Weissman, Ronald D Vale
Cell


Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation.
Luke A Gilbert, Max A Horlbeck, Britt Adamson, Jacqueline E Villalta, Yuwen Chen, Evan H Whitehead, Carla Guimaraes, Barbara Panning, Hidde L Ploegh, Michael C Bassik, Lei S Qi, Martin Kampmann, Jonathan S Weissman
Cell


Unraveling the mechanism of cell death induced by chemical fibrils.
Olivier Julien, Martin Kampmann, Michael C Bassik, Julie A Zorn, Vincent J Venditto, Kazutaka Shimbo, Nicholas J Agard, Kenichi Shimada, Arnold L Rheingold, Brent R Stockwell, Jonathan S Weissman, James A Wells
Nature chemical biology


Ribosome profiling reveals pervasive translation outside of annotated protein-coding genes.
Nicholas T Ingolia, Gloria A Brar, Noam Stern-Ginossar, Michael S Harris, Gaëlle J S Talhouarne, Sarah E Jackson, Mark R Wills, Jonathan S Weissman
Cell reports


Misfolded proteins induce aggregation of the lectin Yos9.
Melanie H Smith, Edwin H Rodriguez, Jonathan S Weissman
The Journal of biological chemistry


The coding and noncoding architecture of the Caulobacter crescentus genome.
Jared M Schrader, Bo Zhou, Gene-Wei Li, Keren Lasker, W Seth Childers, Brandon Williams, Tao Long, Sean Crosson, Harley H McAdams, Jonathan S Weissman, Lucy Shapiro
PLoS genetics


Functional genomics platform for pooled screening and generation of mammalian genetic interaction maps.
Martin Kampmann, Michael C Bassik, Jonathan S Weissman
Nature protocols


A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation.
Michael L van de Weijer, Michael C Bassik, Rutger D Luteijn, Cornelia M Voorburg, Mirjam A M Lohuis, Elisabeth Kremmer, Rob C Hoeben, Emily M LeProust, Siyuan Chen, Hanneke Hoelen, Maaike E Ressing, Weronika Patena, Jonathan S Weissman, Michael T McManus, Emmanuel J H J Wiertz, Robert Jan Lebbink
Nature communications


A pause sequence enriched at translation start sites drives transcription dynamics in vivo.
Matthew H Larson, Rachel A Mooney, Jason M Peters, Tricia Windgassen, Dhananjaya Nayak, Carol A Gross, Steven M Block, William J Greenleaf, Robert Landick, Jonathan S Weissman
Science


Quantifying absolute protein synthesis rates reveals principles underlying allocation of cellular resources.
Gene-Wei Li, David Burkhardt, Carol Gross, Jonathan S Weissman
Cell


Extensive and coordinated control of allele-specific expression by both transcription and translation in Candida albicans.
Dale Muzzey, Gavin Sherlock, Jonathan S Weissman
Genome research


Uniform nomenclature for the mitochondrial contact site and cristae organizing system.
Nikolaus Pfanner, Martin van der Laan, Paolo Amati, Roderick A Capaldi, Amy A Caudy, Agnieszka Chacinska, Manjula Darshi, Markus Deckers, Suzanne Hoppins, Tateo Icho, Stefan Jakobs, Jianguo Ji, Vera Kozjak-Pavlovic, Chris Meisinger, Paul R Odgren, Sang Ki Park, Peter Rehling, Andreas S Reichert, M Saeed Sheikh, Susan S Taylor, Nobuo Tsuchida, Alexander M van der Bliek, Ida J van der Klei, Jonathan S Weissman, Benedikt Westermann, Jiping Zha, Walter Neupert, Jodi Nunnari
The Journal of cell biology


Differential scales of protein quality control.
Suzanne Wolff, Jonathan S Weissman, Andrew Dillin
Cell


KSHV 2.0: a comprehensive annotation of the Kaposi's sarcoma-associated herpesvirus genome using next-generation sequencing reveals novel genomic and functional features.
Carolina Arias, Ben Weisburd, Noam Stern-Ginossar, Alexandre Mercier, Alexis S Madrid, Priya Bellare, Meghan Holdorf, Jonathan S Weissman, Don Ganem
PLoS pathogens

2013


Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system.
Baohui Chen, Luke A Gilbert, Beth A Cimini, Joerg Schnitzbauer, Wei Zhang, Gene-Wei Li, Jason Park, Elizabeth H Blackburn, Jonathan S Weissman, Lei S Qi, Bo Huang
Cell


Genome-wide probing of RNA structure reveals active unfolding of mRNA structures in vivo.
Silvi Rouskin, Meghan Zubradt, Stefan Washietl, Manolis Kellis, Jonathan S Weissman
Nature


Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster.
Joshua G Dunn, Catherine K Foo, Nicolette G Belletier, Elizabeth R Gavis, Jonathan S Weissman
eLife


Msn2 coordinates a stoichiometric gene expression program.
Jacob Stewart-Ornstein, Christopher Nelson, Joe DeRisi, Jonathan S Weissman, Hana El-Samad
Current biology


Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens.
Christina J Matheny, Michael C Wei, Michael C Bassik, Alicia J Donnelly, Martin Kampmann, Masayuki Iwasaki, Obdulio Piloto, David E Solow-Cordero, Donna M Bouley, Rachel Rau, Patrick Brown, Michael T McManus, Jonathan S Weissman, Michael L Cleary
Chemistry & biology


Global cellular response to chemotherapy-induced apoptosis.
Arun P Wiita, Etay Ziv, Paul J Wiita, Anatoly Urisman, Olivier Julien, Alma L Burlingame, Jonathan S Weissman, James A Wells
eLife


Selective ribosome profiling as a tool for studying the interaction of chaperones and targeting factors with nascent polypeptide chains and ribosomes.
Annemarie H Becker, Eugene Oh, Jonathan S Weissman, Günter Kramer, Bernd Bukau
Nature protocols


CRISPR interference (CRISPRi) for sequence-specific control of gene expression.
Matthew H Larson, Luke A Gilbert, Xiaowo Wang, Wendell A Lim, Jonathan S Weissman, Lei S Qi
Nature protocols


A developmentally regulated translational control pathway establishes the meiotic chromosome segregation pattern.
Luke E Berchowitz, Aaron S Gajadhar, Folkert J van Werven, Alexandra A De Rosa, Mariya L Samoylova, Gloria A Brar, Yifeng Xu, Che Xiao, Bruce Futcher, Jonathan S Weissman, Forest M White, Angelika Amon
Genes & development


Assembly of a phased diploid Candida albicans genome facilitates allele-specific measurements and provides a simple model for repeat and indel structure.
Dale Muzzey, Katja Schwartz, Jonathan S Weissman, Gavin Sherlock
Genome biology


CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes.
Luke A Gilbert, Matthew H Larson, Leonardo Morsut, Zairan Liu, Gloria A Brar, Sandra E Torres, Noam Stern-Ginossar, Onn Brandman, Evan H Whitehead, Jennifer A Doudna, Wendell A Lim, Jonathan S Weissman, Lei S Qi
Cell


Genome-wide annotation and quantitation of translation by ribosome profiling.
Nicholas T Ingolia, Gloria A Brar, Silvia Rouskin, Anna M McGeachy, Jonathan S Weissman
Current protocols in molecular biology


Ribosome profiling provides evidence that large noncoding RNAs do not encode proteins.
Mitchell Guttman, Pamela Russell, Nicholas T Ingolia, Jonathan S Weissman, Eric S Lander
Cell


Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells.
Martin Kampmann, Michael C Bassik, Jonathan S Weissman
PNAS


rRNA:mRNA pairing alters the length and the symmetry of mRNA-protected fragments in ribosome profiling experiments.
Patrick B F O'Connor, Gene-Wei Li, Jonathan S Weissman, John F Atkins, Pavel V Baranov
Bioinformatics (Oxford, England)


Aneuploid yeast strains exhibit defects in cell growth and passage through START.
Rebecca R Thorburn, Christian Gonzalez, Gloria A Brar, Stefan Christen, Thomas M Carlile, Nicholas T Ingolia, Uwe Sauer, Jonathan S Weissman, Angelika Amon
Molecular biology of the cell


Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression.
Lei S Qi, Matthew H Larson, Luke A Gilbert, Jennifer A Doudna, Jonathan S Weissman, Adam P Arkin, Wendell A Lim
Cell


A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility.
Michael C Bassik, Martin Kampmann, Robert Jan Lebbink, Shuyi Wang, Marco Y Hein, Ina Poser, Jimena Weibezahn, Max A Horlbeck, Siyuan Chen, Matthias Mann, Anthony A Hyman, Emily M Leproust, Michael T McManus, Jonathan S Weissman
Cell


The contribution of systematic approaches to characterizing the proteins and functions of the endoplasmic reticulum.
Maya Schuldiner, Jonathan S Weissman
Cold Spring Harbor perspectives in biology

2012


Decoding human cytomegalovirus.
Noam Stern-Ginossar, Ben Weisburd, Annette Michalski, Vu Thuy Khanh Le, Marco Y Hein, Sheng-Xiong Huang, Ming Ma, Ben Shen, Shu-Bing Qian, Hartmut Hengel, Matthias Mann, Nicholas T Ingolia, Jonathan S Weissman
Science


A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress.
Onn Brandman, Jacob Stewart-Ornstein, Daisy Wong, Adam Larson, Christopher C Williams, Gene-Wei Li, Sharleen Zhou, David King, Peter S Shen, Jimena Weibezahn, Joshua G Dunn, Silvi Rouskin, Toshifumi Inada, Adam Frost, Jonathan S Weissman
Cell


The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments.
Nicholas T Ingolia, Gloria A Brar, Silvia Rouskin, Anna M McGeachy, Jonathan S Weissman
Nature protocols


Proto-genes and de novo gene birth.
Anne-Ruxandra Carvunis, Thomas Rolland, Ilan Wapinski, Michael A Calderwood, Muhammed A Yildirim, Nicolas Simonis, Benoit Charloteaux, César A Hidalgo, Justin Barbette, Balaji Santhanam, Gloria A Brar, Jonathan S Weissman, Aviv Regev, Nicolas Thierry-Mieg, Michael E Cusick, Marc Vidal
Nature


Functional repurposing revealed by comparing S. pombe and S. cerevisiae genetic interactions.
Adam Frost, Marc G Elgort, Onn Brandman, Clinton Ives, Sean R Collins, Lakshmi Miller-Vedam, Jimena Weibezahn, Marco Y Hein, Ina Poser, Matthias Mann, Anthony A Hyman, Jonathan S Weissman
Cell


Special issue: the molecular and cellular mechanisms of amyloidosis.
Sheena E Radford, Jonathan S Weissman
Journal of molecular biology


Native elongating transcript sequencing (NET-seq).
L Stirling Churchman, Jonathan S Weissman
Current protocols in molecular biology


The anti-Shine-Dalgarno sequence drives translational pausing and codon choice in bacteria.
Gene-Wei Li, Eugene Oh, Jonathan S Weissman
Nature


The translational landscape of mTOR signalling steers cancer initiation and metastasis.
Andrew C Hsieh, Yi Liu, Merritt P Edlind, Nicholas T Ingolia, Matthew R Janes, Annie Sher, Evan Y Shi, Craig R Stumpf, Carly Christensen, Michael J Bonham, Shunyou Wang, Pingda Ren, Michael Martin, Katti Jessen, Morris E Feldman, Jonathan S Weissman, Kevan M Shokat, Christian Rommel, Davide Ruggero
Nature


Cellular noise regulons underlie fluctuations in Saccharomyces cerevisiae.
Jacob Stewart-Ornstein, Jonathan S Weissman, Hana El-Samad
Molecular cell

2011


High-resolution view of the yeast meiotic program revealed by ribosome profiling.
Gloria A Brar, Moran Yassour, Nir Friedman, Aviv Regev, Nicholas T Ingolia, Jonathan S Weissman
Science


Genetics: Noise rules.
Hana El-Samad, Jonathan S Weissman
Nature


Selective ribosome profiling reveals the cotranslational chaperone action of trigger factor in vivo.
Eugene Oh, Annemarie H Becker, Arzu Sandikci, Damon Huber, Rachna Chaba, Felix Gloge, Robert J Nichols, Athanasios Typas, Carol A Gross, Günter Kramer, Jonathan S Weissman, Bernd Bukau
Cell


Road to ruin: targeting proteins for degradation in the endoplasmic reticulum.
Melanie H Smith, Hidde L Ploegh, Jonathan S Weissman
Science


Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae.
Françoise M Roelants, David K Breslow, Alexander Muir, Jonathan S Weissman, Jeremy Thorner
PNAS


Ribosome profiling of mouse embryonic stem cells reveals the complexity and dynamics of mammalian proteomes.
Nicholas T Ingolia, Liana F Lareau, Jonathan S Weissman
Cell


A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria.
Suzanne Hoppins, Sean R Collins, Ann Cassidy-Stone, Eric Hummel, Rachel M Devay, Laura L Lackner, Benedikt Westermann, Maya Schuldiner, Jonathan S Weissman, Jodi Nunnari
The Journal of cell biology


Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats.
Elena O Gracheva, Julio F Cordero-Morales, José A González-Carcacía, Nicholas T Ingolia, Carlo Manno, Carla I Aranguren, Jonathan S Weissman, David Julius
Nature


H3K4 trimethylation by Set1 promotes efficient termination by the Nrd1-Nab3-Sen1 pathway.
Nihal Terzi, L Stirling Churchman, Lidia Vasiljeva, Jonathan Weissman, Stephen Buratowski
Molecular and cellular biology


Amyloid structure: conformational diversity and consequences.
Brandon H Toyama, Jonathan S Weissman
Annual review of biochemistry


Strain conformation, primary structure and the propagation of the yeast prion [PSI+].
Katherine J Verges, Melanie H Smith, Brandon H Toyama, Jonathan S Weissman
Nature structural & molecular biology


Radically different amyloid conformations dictate the seeding specificity of a chimeric Sup35 prion.
Catherine K Foo, Yumiko Ohhashi, Mark J S Kelly, Motomasa Tanaka, Jonathan S Weissman
Journal of molecular biology


Nascent transcript sequencing visualizes transcription at nucleotide resolution.
L Stirling Churchman, Jonathan S Weissman
Nature

2010


Systematic screen of Schizosaccharomyces pombe deletion collection uncovers parallel evolution of the phosphate signal transduction pathway in yeasts.
Theresa C Henry, Juliette E Power, Christine L Kerwin, Aishat Mohammed, Jonathan S Weissman, Dale M Cameron, Dennis D Wykoff
Eukaryotic cell


The epistemology of cell biology.
Jonathan S Weissman
Molecular biology of the cell


Membranes in balance: mechanisms of sphingolipid homeostasis.
David K Breslow, Jonathan S Weissman
Molecular cell


Mammalian microRNAs predominantly act to decrease target mRNA levels.
Huili Guo, Nicholas T Ingolia, Jonathan S Weissman, David P Bartel
Nature


Automated identification of pathways from quantitative genetic interaction data.
Alexis Battle, Martin C Jonikas, Peter Walter, Jonathan S Weissman, Daphne Koller
Molecular systems biology


A general lack of compensation for gene dosage in yeast.
Michael Springer, Jonathan S Weissman, Marc W Kirschner
Molecular systems biology


J domain co-chaperone specificity defines the role of BiP during protein translocation.
Shruthi S Vembar, Martin C Jonikas, Linda M Hendershot, Jonathan S Weissman, Jeffrey L Brodsky
The Journal of biological chemistry


Molecular basis of infrared detection by snakes.
Elena O Gracheva, Nicholas T Ingolia, Yvonne M Kelly, Julio F Cordero-Morales, Gunther Hollopeter, Alexander T Chesler, Elda E Sánchez, John C Perez, Jonathan S Weissman, David Julius
Nature


Orm family proteins mediate sphingolipid homeostasis.
David K Breslow, Sean R Collins, Bernd Bodenmiller, Ruedi Aebersold, Kai Simons, Andrej Shevchenko, Christer S Ejsing, Jonathan S Weissman
Nature


Differences in prion strain conformations result from non-native interactions in a nucleus.
Yumiko Ohhashi, Kazuki Ito, Brandon H Toyama, Jonathan S Weissman, Motomasa Tanaka
Nature chemical biology

2009


From information to knowledge: new technologies for defining gene function.
Sean R Collins, Jonathan S Weissman, Nevan J Krogan
Nature methods


Journal club. A biochemist looks at how DNA sequencing can reveal more than just sequences.
Jonathan Weissman
Nature


Regulated Ire1-dependent decay of messenger RNAs in mammalian cells.
Julie Hollien, Jonathan H Lin, Han Li, Nicole Stevens, Peter Walter, Jonathan S Weissman
The Journal of cell biology


An ER-mitochondria tethering complex revealed by a synthetic biology screen.
Benoît Kornmann, Erin Currie, Sean R Collins, Maya Schuldiner, Jodi Nunnari, Jonathan S Weissman, Peter Walter
Science


Rapid creation and quantitative monitoring of high coverage shRNA libraries.
Michael C Bassik, Robert Jan Lebbink, L Stirling Churchman, Nicholas T Ingolia, Weronika Patena, Emily M LeProust, Maya Schuldiner, Jonathan S Weissman, Michael T McManus
Nature methods


Analysis of Dom34 and its function in no-go decay.
Dario O Passos, Meenakshi K Doma, Christopher J Shoemaker, Denise Muhlrad, Rachel Green, Jonathan Weissman, Julie Hollien, Roy Parker
Molecular biology of the cell


Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum.
Martin C Jonikas, Sean R Collins, Vladimir Denic, Eugene Oh, Erin M Quan, Volker Schmid, Jimena Weibezahn, Blanche Schwappach, Peter Walter, Jonathan S Weissman, Maya Schuldiner
Science


Functional organization of the S. cerevisiae phosphorylation network.
Dorothea Fiedler, Hannes Braberg, Monika Mehta, Gal Chechik, Gerard Cagney, Paromita Mukherjee, Andrea C Silva, Michael Shales, Sean R Collins, Sake van Wageningen, Patrick Kemmeren, Frank C P Holstege, Jonathan S Weissman, Michael-Christopher Keogh, Daphne Koller, Kevan M Shokat, Nevan J Krogan
Cell


Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling.
Nicholas T Ingolia, Sina Ghaemmaghami, John R S Newman, Jonathan S Weissman
Science


High-throughput, quantitative analyses of genetic interactions in E. coli.
Athanasios Typas, Robert J Nichols, Deborah A Siegele, Michael Shales, Sean R Collins, Bentley Lim, Hannes Braberg, Natsuko Yamamoto, Rikiya Takeuchi, Barry L Wanner, Hirotada Mori, Jonathan S Weissman, Nevan J Krogan, Carol A Gross
Nature methods

2008


Defining the glycan destruction signal for endoplasmic reticulum-associated degradation.
Erin M Quan, Yukiko Kamiya, Daiki Kamiya, Vladimir Denic, Jimena Weibezahn, Koichi Kato, Jonathan S Weissman
Molecular cell


A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing.
Gwendolyn M Wilmes, Megan Bergkessel, Sourav Bandyopadhyay, Michael Shales, Hannes Braberg, Gerard Cagney, Sean R Collins, Gregg B Whitworth, Tracy L Kress, Jonathan S Weissman, Trey Ideker, Christine Guthrie, Nevan J Krogan
Molecular cell


In vivo monitoring of the prion replication cycle reveals a critical role for Sis1 in delivering substrates to Hsp104.
Kimberly A Tipton, Katherine J Verges, Jonathan S Weissman
Molecular cell


Activity motifs reveal principles of timing in transcriptional control of the yeast metabolic network.
Gal Chechik, Eugene Oh, Oliver Rando, Jonathan Weissman, Aviv Regev, Daphne Koller
Nature biotechnology


Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast.
Assen Roguev, Sourav Bandyopadhyay, Martin Zofall, Ke Zhang, Tamas Fischer, Sean R Collins, Hongjing Qu, Michael Shales, Han-Oh Park, Jacqueline Hayles, Kwang-Lae Hoe, Dong-Uk Kim, Trey Ideker, Shiv I Grewal, Jonathan S Weissman, Nevan J Krogan
Science


Systems biology: Reverse engineering the cell.
Nicholas T Ingolia, Jonathan S Weissman
Nature


The GET complex mediates insertion of tail-anchored proteins into the ER membrane.
Maya Schuldiner, Jutta Metz, Volker Schmid, Vladimir Denic, Magdalena Rakwalska, Hans Dieter Schmitt, Blanche Schwappach, Jonathan S Weissman
Cell


Construction, verification and experimental use of two epitope-tagged collections of budding yeast strains.
Russell Howson, Won-Ki Huh, Sina Ghaemmaghami, James V Falvo, Kiowa Bower, Archana Belle, Noah Dephoure, Dennis D Wykoff, Jonathan S Weissman, Erin K O'Shea
Comparative and functional genomics


A comprehensive strategy enabling high-resolution functional analysis of the yeast genome.
David K Breslow, Dale M Cameron, Sean R Collins, Maya Schuldiner, Jacob Stewart-Ornstein, Heather W Newman, Sigurd Braun, Hiten D Madhani, Nevan J Krogan, Jonathan S Weissman
Nature methods


Small-molecule aggregates inhibit amyloid polymerization.
Brian Y Feng, Brandon H Toyama, Holger Wille, David W Colby, Sean R Collins, Barnaby C H May, Stanley B Prusiner, Jonathan Weissman, Brian K Shoichet
Nature chemical biology

2007


Identification of yeast proteins necessary for cell-surface function of a potassium channel.
Friederike A Haass, Martin Jonikas, Peter Walter, Jonathan S Weissman, Yuh-Nung Jan, Lily Y Jan, Maya Schuldiner
PNAS


High-throughput genetic interaction mapping in the fission yeast Schizosaccharomyces pombe.
Assen Roguev, Marianna Wiren, Jonathan S Weissman, Nevan J Krogan
Nature methods


The structural basis of yeast prion strain variants.
Brandon H Toyama, Mark J S Kelly, John D Gross, Jonathan S Weissman
Nature


A molecular caliper mechanism for determining very long-chain fatty acid length.
Vladimir Denic, Jonathan S Weissman
Cell


Mec1/Tel1 phosphorylation of the INO80 chromatin remodeling complex influences DNA damage checkpoint responses.
Ashby J Morrison, Jung-Ae Kim, Maria D Person, Jessica Highland, Jing Xiao, Tammy S Wehr, Sean Hensley, Yunhe Bao, Jianjun Shen, Sean R Collins, Jonathan S Weissman, Jeff Delrow, Nevan J Krogan, James E Haber, Xuetong Shen
Cell


Backup without redundancy: genetic interactions reveal the cost of duplicate gene loss.
Jan Ihmels, Sean R Collins, Maya Schuldiner, Nevan J Krogan, Jonathan S Weissman
Molecular systems biology


CCR4/NOT complex associates with the proteasome and regulates histone methylation.
R Nicholas Laribee, Yoichiro Shibata, Douglas P Mersman, Sean R Collins, Patrick Kemmeren, Assen Roguev, Jonathan S Weissman, Scott D Briggs, Nevan J Krogan, Brian D Strahl
PNAS


Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map.
Sean R Collins, Kyle M Miller, Nancy L Maas, Assen Roguev, Jeffrey Fillingham, Clement S Chu, Maya Schuldiner, Marinella Gebbia, Judith Recht, Michael Shales, Huiming Ding, Hong Xu, Junhong Han, Kristin Ingvarsdottir, Benjamin Cheng, Brenda Andrews, Charles Boone, Shelley L Berger, Phil Hieter, Zhiguo Zhang, Grant W Brown, C James Ingles, Andrew Emili, C David Allis, David P Toczyski, Jonathan S Weissman, Jack F Greenblatt, Nevan J Krogan
Nature


Toward a comprehensive atlas of the physical interactome of Saccharomyces cerevisiae.
Sean R Collins, Patrick Kemmeren, Xue-Chu Zhao, Jack F Greenblatt, Forrest Spencer, Frank C P Holstege, Jonathan S Weissman, Nevan J Krogan
Molecular & cellular proteomics

2006


Systems biology: many things from one.
John R S Newman, Jonathan S Weissman
Nature


An efficient protein transformation protocol for introducing prions into yeast.
Motomasa Tanaka, Jonathan S Weissman
Methods in enzymology


A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradation.
Vladimir Denic, Erin M Quan, Jonathan S Weissman
Cell


A strategy for extracting and analyzing large-scale quantitative epistatic interaction data.
Sean R Collins, Maya Schuldiner, Nevan J Krogan, Jonathan S Weissman
Genome biology


Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.
Julie Hollien, Jonathan S Weissman
Science


The physical basis of how prion conformations determine strain phenotypes.
Motomasa Tanaka, Sean R Collins, Brandon H Toyama, Jonathan S Weissman
Nature


Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise.
John R S Newman, Sina Ghaemmaghami, Jan Ihmels, David K Breslow, Matthew Noble, Joseph L DeRisi, Jonathan S Weissman
Nature


Molecular chaperones and protein quality control.
Bernd Bukau, Jonathan Weissman, Arthur Horwich
Cell


Global landscape of protein complexes in the yeast Saccharomyces cerevisiae.
Nevan J Krogan, Gerard Cagney, Haiyuan Yu, Gouqing Zhong, Xinghua Guo, Alexandr Ignatchenko, Joyce Li, Shuye Pu, Nira Datta, Aaron P Tikuisis, Thanuja Punna, José M Peregrín-Alvarez, Michael Shales, Xin Zhang, Michael Davey, Mark D Robinson, Alberto Paccanaro, James E Bray, Anthony Sheung, Bryan Beattie, Dawn P Richards, Veronica Canadien, Atanas Lalev, Frank Mena, Peter Wong, Andrei Starostine, Myra M Canete, James Vlasblom, Samuel Wu, Chris Orsi, Sean R Collins, Shamanta Chandran, Robin Haw, Jennifer J Rilstone, Kiran Gandi, Natalie J Thompson, Gabe Musso, Peter St Onge, Shaun Ghanny, Mandy H Y Lam, Gareth Butland, Amin M Altaf-Ul, Shigehiko Kanaya, Ali Shilatifard, Erin O'Shea, Jonathan S Weissman, C James Ingles, Timothy R Hughes, John Parkinson, Mark Gerstein, Shoshana J Wodak, Andrew Emili, Jack F Greenblatt
Nature

2005


Domain architecture of protein-disulfide isomerase facilitates its dual role as an oxidase and an isomerase in Ero1p-mediated disulfide formation.
Mohini S Kulp, Eva-Maria Frickel, Lars Ellgaard, Jonathan S Weissman
The Journal of biological chemistry


Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex.
Michael-Christopher Keogh, Siavash K Kurdistani, Stephanie A Morris, Seong Hoon Ahn, Vladimir Podolny, Sean R Collins, Maya Schuldiner, Kayu Chin, Thanuja Punna, Natalie J Thompson, Charles Boone, Andrew Emili, Jonathan S Weissman, Timothy R Hughes, Brian D Strahl, Michael Grunstein, Jack F Greenblatt, Stephen Buratowski, Nevan J Krogan
Cell


Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile.
Maya Schuldiner, Sean R Collins, Natalie J Thompson, Vladimir Denic, Arunashree Bhamidipati, Thanuja Punna, Jan Ihmels, Brenda Andrews, Charles Boone, Jack F Greenblatt, Jonathan S Weissman, Nevan J Krogan
Cell


Exploration of the topological requirements of ERAD identifies Yos9p as a lectin sensor of misfolded glycoproteins in the ER lumen.
Arunashree Bhamidipati, Vladimir Denic, Erin M Quan, Jonathan S Weissman
Molecular cell


Mechanism of cross-species prion transmission: an infectious conformation compatible with two highly divergent yeast prion proteins.
Motomasa Tanaka, Peter Chien, Koji Yonekura, Jonathan S Weissman
Cell

2004


2004 Irving Sigal Young Investigator Award.
Jonathan S Weissman, Erin K O'Shea
Protein science : a publication of the Protein Society


Mechanism of prion propagation: amyloid growth occurs by monomer addition.
Sean R Collins, Adam Douglass, Ronald D Vale, Jonathan S Weissman
PLoS biology


Emerging principles of conformation-based prion inheritance.
Peter Chien, Jonathan S Weissman, Angela H DePace
Annual review of biochemistry


Dissection and design of yeast prions.
Lev Z Osherovich, Brian S Cox, Mick F Tuite, Jonathan S Weissman
PLoS biology


Conformational variations in an infectious protein determine prion strain differences.
Motomasa Tanaka, Peter Chien, Nariman Naber, Roger Cooke, Jonathan S Weissman
Nature


Oxidative protein folding in eukaryotes: mechanisms and consequences.
Benjamin P Tu, Jonathan S Weissman
The Journal of cell biology

2003


Global analysis of protein expression in yeast.
Sina Ghaemmaghami, Won-Ki Huh, Kiowa Bower, Russell W Howson, Archana Belle, Noah Dephoure, Erin K O'Shea, Jonathan S Weissman
Nature


Global analysis of protein localization in budding yeast.
Won-Ki Huh, James V Falvo, Luke C Gerke, Adam S Carroll, Russell W Howson, Jonathan S Weissman, Erin K O'Shea
Nature


Generation of prion transmission barriers by mutational control of amyloid conformations.
Peter Chien, Angela H DePace, Sean R Collins, Jonathan S Weissman
Nature


Directed evolution of substrate-optimized GroEL/S chaperonins.
Jue D Wang, Christophe Herman, Kimberly A Tipton, Carol A Gross, Jonathan S Weissman
Cell

2002


The FAD- and O(2)-dependent reaction cycle of Ero1-mediated oxidative protein folding in the endoplasmic reticulum.
Benjamin P Tu, Jonathan S Weissman
Molecular cell


Origins and kinetic consequences of diversity in Sup35 yeast prion fibers.
Angela H DePace, Jonathan S Weissman
Nature structural biology


The utility of prions.
Lev Z Osherovich, Jonathan S Weissman
Developmental cell