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Perturb-seq is an experimental approach to map the transcriptional effects of genetic perturbations by combining CRISPR-based genetic screening with information-rich, single-cell RNA-sequencing phenotypes.
Applied at genome-scale, Perturb-seq enables systematic prediction of gene function and in-depth study of complex cellular phenotypes such as aneuploidy, differentiation, RNA processing, and stress-specific regulation of the mitochondrial genome.